A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21636 |
| Swiss-prot Accession number | Q9Y271 (Sequence in FASTA format) |
| Description | Cysteinyl leukotriene receptor 1;CysLTR1;Alternative Name: Cysteinyl leukotriene D4 receptor;LTD4 receptor;Alternative Name: HG55;Alternative Name: HMTMF81 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart. |
| Post translational modification | N/A |
| Function | Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. |
| Protein Length | 337 Amino acids |
| Molecular weight | 38541 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 10391245 2 PubMed abstract 10462554 3 PubMed abstract 15772651 4 PubMed abstract 15489334 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 10800 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |