A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21637 |
| Swiss-prot Accession number | Q9NPC1 (Sequence in FASTA format) |
| Description | Leukotriene B4 receptor 2;LTB4-R2;Alternative Name: Seven transmembrane receptor BLTR2;Alternative Name: Leukotriene B4 receptor BLT2;Alternative Name: LTB4 receptor JULF2 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Widely expressed. |
| Post translational modification | N/A |
| Function | Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. |
| Protein Length | 389 Amino acids |
| Molecular weight | 41525 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 10913346 2 PubMed abstract 10934230 3 PubMed abstract 11006272 4 PubMed abstract 10889186 5 PubMed abstract 12044878 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 56413 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |