A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 22954 |
| Swiss-prot Accession number | Q9MYL0 (Sequence in FASTA format) |
| Description | Leptin receptor;LEP-R;Alternative Name: OB receptor;OB-R;Alternative Name: CD_antigen=CD295;Precursor |
| Source organism | Macaca mulatta (Rhesus macaque) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. |
| Subcellular location | Membrane; Single-pass type I membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. |
| Tissue Specificity | Widely expressed. High expression of isoform B in liver, adipose tissue, hypothalamus and choroid plexus. |
| Post translational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-984 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1139 is required for STAT3 binding/activation (By similarity). |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3 (By similarity). Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity). The short form (isoform A) may act to transport leptin to the cerebrospinal fluid (By similarity). |
| Protein Length | 1163 Amino acids |
| Molecular weight | 132296 |
| Domain Name | fn3 Lep_receptor_Ig |
| References | 1 PubMed abstract 9738551 |
| Hormone | Q28504 Detail in HMRbase |
| Gene ID | 574126 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |