A database of hormones and their receptors
Peptide Hormone

Search Result - 1

HMRbase accession number10115
Swiss-prot Accession numberQ9GKY5 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin].
Source organismSus scrofa (Pig)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular locationSecreted protein (By similarity)
Developmental StageN/A
Similarity Belongs to the motilin family.
Tissue SpecificityN/A
Post translational modification O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-99 is essential for obestatin activity (By similarity).
FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation
Protein Length118 Amino acids
Molecular weight12786
References1   Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
2   Rousselle J., Lacroix D., Dubreuil P.; Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
3   Ying M., Yang Z.; Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameGhrelin
Mature Hormone SequenceGSSFLSPEHQKVQQRKESKKPAAKLKPR
Position of mature hormone in Pre-Hormone protein28 Residues from position (25-52)
ReceptorP34999    Detail in HMRbase   
Gene ID396728      
PDB IDN/A
Drugpediawiki
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Search Result - 2

HMRbase accession number10352
Swiss-prot Accession numberQ9GKY5 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide)[Contains: Ghrelin; Obestatin].
Source organismSus scrofa (Pig)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;Sus.
Subcellular locationSecreted protein (By similarity)
Developmental StageN/A
Similarity Belongs to the motilin family.
Tissue SpecificityN/A
Post translational modification O-n-octanoylation is essential for ghrelin activity (By similarity). Amidation of Leu-99 is essential for obestatin activity (By similarity).
FunctionObestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility
Protein Length118 Amino acids
Molecular weight12786
References1   Kojima M.; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
2   Rousselle J., Lacroix D., Dubreuil P.; Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
3   Ying M., Yang Z.; Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameObestatin
Mature Hormone SequenceFNAPCDVGIKLSGAQSDQHGQPL
Position of mature hormone in Pre-Hormone protein23 Residues from position (77-99)
ReceptorP34999    Detail in HMRbase   
Gene ID396728      
PDB IDN/A
Drugpediawiki
Comments