A database of hormones and their receptors
Peptide Hormone

Search Result - 1

HMRbase accession number11512
Swiss-prot Accession numberQ9EQX0 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin; Obestatin].
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationSecreted protein
Developmental StageLevels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold, respectively, between postnatal weeks 3 and 4 due to change of diet during weaning.
Similarity Belongs to the motilin family.
Tissue SpecificityMainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung
Post translational modification O-n-octanoylation is essential for ghrelin activity (By similarity). The O-n-decanoylated form ghrelin-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. Amidation of Leu-98 is essential for obestatin activity (By similarity).
FunctionGhrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation
Protein Length117 Amino acids
Molecular weight13207
References1  PubMed abstract 10930375
2   Kojima M.; "Mouse mRNA for preproghrelin."; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
3   Tanaka M., Hayashida Y., Iguchi T., Nakao N., Nakai N., Nakashima K.; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
4  PubMed abstract 16141072
5  PubMed abstract 15746259
6  PubMed abstract 11306336
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameGhrelin
Mature Hormone SequenceGSSFLSPEHQKAQQRKESKKPPAKLQPR
Position of mature hormone in Pre-Hormone protein28 Residues from position (24-51)
ReceptorQ99P50    Detail in HMRbase   
Gene ID58991      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 2

HMRbase accession number11513
Swiss-prot Accession numberQ9EQX0 (Sequence in FASTA format)
DescriptionAppetite-regulating hormone precursor (Growth hormone secretagogue)(Growth hormone-releasing peptide) (Motilin-related peptide) (M46protein) [Contains: Ghrelin; Obestatin].
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationSecreted protein
Developmental StageLevels of n-octanoylated and n-decanoylated ghrelin drop by one third and 3-fold, respectively, between postnatal weeks 3 and 4 due to change of diet during weaning.
Similarity Belongs to the motilin family.
Tissue SpecificityMainly expressed in the gastrointestinal tract with higher levels in the stomach, medium levels in the duodenum, jejunum, ileum and colon. Low expression in the testis and brain. Not detected in the salivary gland, pancreas, liver and lung
Post translational modification O-n-octanoylation is essential for ghrelin activity (By similarity). The O-n-decanoylated form ghrelin-C10 differs in the length of the carbon backbone of the carboxylic acid bound to Ser- 26. Amidation of Leu-98 is essential for obestatin activity (By similarity).
FunctionObestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility
Protein Length117 Amino acids
Molecular weight13207
References1  PubMed abstract 10930375
2   Kojima M.; "Mouse mRNA for preproghrelin."; Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
3   Tanaka M., Hayashida Y., Iguchi T., Nakao N., Nakai N., Nakashima K.; Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
4  PubMed abstract 16141072
5  PubMed abstract 15746259
6  PubMed abstract 11306336
Domain NameMotilin_assoc  Motilin_ghrelin  
Hormone NameObestatin
Mature Hormone SequenceFNAPFDVGIKLSGAQYQQHGRAL
Position of mature hormone in Pre-Hormone protein23 Residues from position (76-98)
ReceptorQ99P50    Detail in HMRbase   
Gene ID58991      
PDB IDN/A
Drugpediawiki
Comments