A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21363 |
| Swiss-prot Accession number | Q96RI1 (Sequence in FASTA format) |
| Description | RecName: Bile acid receptor;Alternative Name: Farnesoid X-activated receptor;Alternative Name: Farnesol receptor HRR-1;Alternative Name: Nuclear receptor subfamily 1 group H member 4;Alternative Name: Retinoid X receptor-interacting protein 14;RXR-interacting protein 14; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus. |
| Protein Length | 486 Amino acids |
| Molecular weight | 55914 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 12062799 2 PubMed abstract 10334992 3 PubMed abstract 10334993 4 PubMed abstract 12917342 5 PubMed abstract 15471871 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 9971 |
| PDB ID | 1OSH 1OSK 3BEJ |
| Drugpedia | wiki |
| Comments |