A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21141 |
| Swiss-prot Accession number | Q8CH60 (Sequence in FASTA format) |
| Description | Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). |
| Source organism | Cavia porcellus (Guinea pig) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;Hystricognathi; Caviidae; Cavia. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 328 Amino acids |
| Molecular weight | 37690 |
| Domain Name | 7tm_1 |
| References | 1 Fujii Y., Ikemoto T., Park M.K.; "Molecular cloning of a GnRH receptor in the guinea pig."; Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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| Hormone | O54713 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |