A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21103 |
| Swiss-prot Accession number | Q5GJ04 (Sequence in FASTA format) |
| Description | Follicle-stimulating hormone receptor precursor (FSH-R) (Follitropinreceptor). |
| Source organism | Felis silvestris catus (Cat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;Felinae; Felis. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. Contains 10 LRR (leucine-rich) repeats. |
| Tissue Specificity | N/A |
| Post translational modification | N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone (By similarity). |
| Function | Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). |
| Protein Length | 695 Amino acids |
| Molecular weight | 78829 |
| Domain Name | N/A |
| References | 1 Neubauer K., Fickel J., Jewgenow K.; "Cloning and sequencing of cat FSH receptor cDNA."; Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
2 Neubauer K., Fickel J., Jewgenow K.; "Cloning and sequencing of cat FSH receptor cDNA."; Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases. |
| Hormone | Q52R91 Detail in HMRbase |
| Gene ID | 554348 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |