A database of hormones and their receptors
Receptor

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HMRbase accession number21334
Swiss-prot Accession numberQ29131 (Sequence in FASTA format)
DescriptionRecName: Mineralocorticoid receptor;MR;Alternative Name: Nuclear receptor subfamily 3 group C member 2;
Source organismTupaia glis belangeri (Common tree shrew)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
Subcellular locationCytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding (By similarity)
Developmental StageN/A
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue SpecificityN/A
Post translational modification N/A
Function Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity).
Protein Length977 Amino acids
Molecular weight106489
Domain NameHormone_recep  zf-C4  
References1  PubMed abstract 9582428
HormoneDetail in HMRbase   
Gene IDN/A
PDB IDN/A
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