A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21635 |
| Swiss-prot Accession number | Q15722 (Sequence in FASTA format) |
| Description | Leukotriene B4 receptor 1;LTB4-R 1;Alternative Name: P2Y purinoceptor 7;P2Y7;Alternative Name: Chemoattractant receptor-like 1;Alternative Name: G-protein coupled receptor 16 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver. High level of expression in lymphoid tissues. |
| Post translational modification | Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization. |
| Function | Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. |
| Protein Length | 352 Amino acids |
| Molecular weight | 37557 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8702478 2 PubMed abstract 8558062 3 PubMed abstract 9177352 4 PubMed abstract 8921391 5 PubMed abstract 10934229 6 PubMed abstract 15489334 7 PubMed abstract 12077128 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 1241 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |