A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21073 |
| Swiss-prot Accession number | Q13324 (Sequence in FASTA format) |
| Description | Corticotropin-releasing factor receptor 2 precursor (CRF-R 2) (CRF2)(Corticotropin-releasing hormone receptor 2) (CRH-R 2). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
| Protein Length | 411 Amino acids |
| Molecular weight | 47688 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 8536644 2 Kostich W.A., Chen A., Sperle K., Horlick R.A., Patterson J.,Hyde T.M., Largent B.L.; "Molecular cloning of the human CRH2B receptor isoform: divergencefrom the rodent isoform in sequence and expression pattern."; Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 9717834 4 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 5 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 12853948 7 PubMed abstract 15489334 8 PubMed abstract 9199241 9 PubMed abstract 8536644 10 Kostich W.A., Chen A., Sperle K., Horlick R.A., Patterson J.,Hyde T.M., Largent B.L.; "Molecular cloning of the human CRH2B receptor isoform: divergencefrom the rodent isoform in sequence and expression pattern."; Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases. 11 PubMed abstract 9717834 12 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 13 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. 14 PubMed abstract 12853948 15 PubMed abstract 15489334 16 PubMed abstract 9199241 |
| Hormone | P06850 Detail in HMRbase |
| Gene ID | 1395 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |