A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21245 |
| Swiss-prot Accession number | P62508 (Sequence in FASTA format) |
| Description | RecName: Estrogen-related receptor gamma;Alternative Name: Estrogen receptor-related protein 3;Alternative Name: ERR gamma-2;Alternative Name: Nuclear receptor subfamily 3 group B member 3; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (Probable) |
| Developmental Stage | Expressed at high levels in fetal brain and also in the fetal kidney, lung and liver. |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in the heart, kidney, brain, lung, bone marrow, adrenal gland, trachea, spinal cord and thyroid gland. |
| Post translational modification | N/A |
| Function | Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). |
| Protein Length | 458 Amino acids |
| Molecular weight | 51306 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 10072763 2 PubMed abstract 10048485 3 PubMed abstract 9676434 4 PubMed abstract 10707956 5 PubMed abstract 16710414 6 PubMed abstract 15489334 7 PubMed abstract 10428842 8 PubMed abstract 14651967 9 PubMed abstract 11864604 10 PubMed abstract 15161930 11 PubMed abstract 16307879 12 PubMed abstract 16990259 |
| Hormone | Detail in HMRbase |
| Gene ID | 2104 |
| PDB ID | 1KV6 1S9P 1S9Q 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z |
| Drugpedia | wiki |
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