A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 22955 |
| Swiss-prot Accession number | P48356 (Sequence in FASTA format) |
| Description | Leptin receptor;LEP-R;Alternative Name: OB receptor;OB-R;Alternative Name: B219;Alternative Name: CD_antigen=CD295;Precursor |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Isoform E: Secreted (Probable) |
| Developmental Stage | N/A |
| Similarity | Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like (immunoglobulin-like) domain. |
| Tissue Specificity | Isoform A: highest level of expression in lung and kidney, also present in kidney, heart, brain, spleen, liver, muscle, choroid plexus and hypothalamus. Isoform B: highest level of expression in hypothalamus and lower level in brain, testes and adipose tissue. Isoform E: expressed in adipose tissue, hypothalamus, heart, and testes. |
| Post translational modification | On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-985 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3. Phosphorylation on Tyr-1138 is required for STAT3 binding/activation. Phosphorylation of Tyr-985 is required for SOCS3 binding and SOCS3 mediated inhibition of leptin signaling, whereas phosphorylation of Tyr-1077 has a more accessory role. |
| Function | Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway. Isoform A may act to transport leptin to the cerebrospinal fluid (By similarity). Isoform E could function as a transport protein. |
| Protein Length | 1162 Amino acids |
| Molecular weight | 130789 |
| Domain Name | fn3 Lep_receptor_Ig |
| References | 1 PubMed abstract 8548812 2 PubMed abstract 8608603 3 PubMed abstract 8628397 4 PubMed abstract 8616721 5 PubMed abstract 8692797 6 PubMed abstract 9322935 7 PubMed abstract 9344648 8 PubMed abstract 9845674 9 PubMed abstract 11108838 10 PubMed abstract 10799542 11 PubMed abstract 11018044 12 PubMed abstract 12196522 |
| Hormone | P41160 Detail in HMRbase Q544U0 Detail in HMRbase |
| Gene ID | 16847 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |