A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21238 |
| Swiss-prot Accession number | P34021 (Sequence in FASTA format) |
| Description | RecName: Ecdysone receptor;Alternative Name: Ecdysteroid receptor;Alternative Name: 20-hydroxy-ecdysone receptor;20E receptor;Alternative Name: EcRH;Alternative Name: Nuclear receptor subfamily 1 group H member 1; |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
| Subcellular location | Nucleus |
| Developmental Stage | In the salivary glands of mid instar larvae levels increase during puff stage 1 at 86-94 hours of development then remain relatively constant until the premetamorphic pulse of ecdysone in late larvae. Levels diminish dramatically from puff stage 7 onwards. Levels increase in the prepupal period during puff stage 13-14, the level remains stable until stage 21. A decrease in levels at puff stage 7 is also seen in the Malpighian tubules and less dramatically in the fat body and gut. In the wing disk the relatively low level remains unchanged. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Isoform B1 predominates over isoform A in larval tissues, imaginal histoblast nests and midgut islands. Isoform A predominates over B1 in imaginal disks, and the larval prothoracic gland. |
| Post translational modification | N/A |
| Function | Receptor for ecdysone. Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes. |
| Protein Length | 878 Amino acids |
| Molecular weight | 93853 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 1913820 2 PubMed abstract 10731132 3 PubMed abstract 12537572 4 PubMed abstract 12537569 5 PubMed abstract 8324824 6 PubMed abstract 8247157 7 PubMed abstract 8223281 8 PubMed abstract 14603321 |
| Hormone | Detail in HMRbase |
| Gene ID | 35540 |
| PDB ID | 1R0N 1R0O 2HAN |
| Drugpedia | wiki |
| Comments |