A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21025 |
| Swiss-prot Accession number | P32237 (Sequence in FASTA format) |
| Description | Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R). |
| Source organism | Ovis aries (Sheep) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Receptor for gonadotropin releasing hormone (GnRH) that mediate the action of GnRH to stimulate the secretion of the gonadotropic hormones (LH and FSH). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| Protein Length | 328 Amino acids |
| Molecular weight | 37685 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7694577 2 PubMed abstract 8224516 3 PubMed abstract 8666259 |
| Hormone | Q28588 Detail in HMRbase |
| Gene ID | 443413 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |