A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21012 |
| Swiss-prot Accession number | P30874 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 2 (SS2R) (SRIF-1). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. |
| Post translational modification | N/A |
| Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. |
| Protein Length | 369 Amino acids |
| Molecular weight | 41333 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1346068 2 PubMed abstract 10619399 3 Kopatz S.A., Aronstam R.S., Sharma S.V.; "Isolation of complete coding sequence for somatostatin receptor 2(SSTR2)."; Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. 4 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 5 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 15489334 7 PubMed abstract 8386508 8 PubMed abstract 10551867 9 PubMed abstract 1346068 10 PubMed abstract 10619399 11 Kopatz S.A., Aronstam R.S., Sharma S.V.; "Isolation of complete coding sequence for somatostatin receptor 2(SSTR2)."; Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. 12 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 13 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 14 PubMed abstract 15489334 15 PubMed abstract 8386508 16 PubMed abstract 10551867 17 PubMed abstract 1346068 18 PubMed abstract 10619399 19 Kopatz S.A., Aronstam R.S., Sharma S.V.; "Isolation of complete coding sequence for somatostatin receptor 2(SSTR2)."; Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. 20 Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. 21 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 22 PubMed abstract 15489334 23 PubMed abstract 8386508 24 PubMed abstract 10551867 |
| Hormone | P61278 Detail in HMRbase |
| Gene ID | 6752 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |