A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21008 |
| Swiss-prot Accession number | P30680 (Sequence in FASTA format) |
| Description | Somatostatin receptor type 2 (SS2R) (SRIF-1). |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cell membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Cortex, hippocampus, pituitary gland, colon adrenals, pancreas-derived cell line and pancreatic tumor. |
| Post translational modification | N/A |
| Function | Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. |
| Protein Length | 369 Amino acids |
| Molecular weight | 41200 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 1374909 2 PubMed abstract 1348934 3 PubMed abstract 8386508 4 PubMed abstract 1374909 5 PubMed abstract 1348934 6 PubMed abstract 8386508 |
| Hormone | P60042 Detail in HMRbase |
| Gene ID | 54305 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |