A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 11434 |
| Swiss-prot Accession number | P27106 (Sequence in FASTA format) |
| Description | Muellerian-inhibiting factor precursor (MIS) (Anti-Muellerian hormone)(AMH) (Muellerian-inhibiting substance). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Secreted protein (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the TGF-beta family. |
| Tissue Specificity | Sertoli cells of fetal testes, and testes just after birth, but absent in adult testes. In female, AMH is expressed after birth in the granulosa cells of the follicle. AMH expression is dependent on the degree of follicular maturation and not on the age of the ovary |
| Post translational modification | N/A |
| Function | This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin |
| Protein Length | 555 Amino acids |
| Molecular weight | 59778 |
| References | 1 PubMed abstract 1782869 2 Dresser D.W., Jamin S., Atkins C.J., Guerrier D.; "A GNRP-like gene shares a bidirectional promoter with SAP62immediately upstream of AMH."; Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases. 3 PubMed abstract 8541848 |
| Domain Name | N/A |
| Hormone Name | Muellerian-inhibiting factor |
| Mature Hormone Sequence | N/A |
| Position of mature hormone in Pre-Hormone protein | N/A Residues from position |
| Receptor | Q8K592
Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |