A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21419 |
| Swiss-prot Accession number | P23204 (Sequence in FASTA format) |
| Description | Peroxisome proliferator-activated receptor alpha;PPAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group C member 1 |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus |
| Developmental Stage | It appears first at 13.5 dpc and increases until birth. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Highly expressed in liver, kidney and heart. Very weakly expressed in brain and testis. |
| Post translational modification | N/A |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. |
| Protein Length | 468 Amino acids |
| Molecular weight | 52347 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2129546 2 PubMed abstract 8123021 3 PubMed abstract 15489334 4 PubMed abstract 7588749 5 PubMed abstract 9325263 6 PubMed abstract 9627117 7 PubMed abstract 10788465 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 19013 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |