A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21230 |
| Swiss-prot Accession number | P17671 (Sequence in FASTA format) |
| Description | RecName: Ecdysone-induced protein 75B, isoforms C/D;Alternative Name: E75-A;Alternative Name: Nuclear receptor subfamily 1 group D member 3, isoforms C/D; |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
| Subcellular location | Nucleus (Potential) |
| Developmental Stage | In mid instar larvae salivary glands, low basal levels are observed in puff stage 1. Levels increase in late larvae from puff stages 3-10, then decrease abruptly at stage 11. In prepupae, isoform C is the predominant form during the transition between puff stages 18-19. At puff stage 1, expression is also present in the gut. By stage 3 it is present in the wing disks, Malpighian tubules and the fat body. At stage 11, expression is only present in the gut and wing disks. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone. |
| Protein Length | 1199 Amino acids |
| Molecular weight | 128534 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2110921 2 PubMed abstract 10731132 3 PubMed abstract 12537572 4 PubMed abstract 8223281 |
| Hormone | Detail in HMRbase |
| Gene ID | 39999 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |