A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21229 |
| Swiss-prot Accession number | P13055 (Sequence in FASTA format) |
| Description | RecName: Ecdysone-induced protein 75B, isoform B;Alternative Name: E75-C;Alternative Name: Nuclear receptor subfamily 1 group D member 3, isoform B; |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
| Subcellular location | Nucleus (Potential) |
| Developmental Stage | In mid instar larvae salivary glands, levels increase during puff stage 1, then remain relatively constant until the premetamorphic pulse of ecdysone at puff stage 5. Levels increase again in late larvae at puff stages 9-10. At puff stage 1 expression is also seen in the gut. Levels are low in the gut, Malpighian tubules, fat body and wing disks between stages 1 and 11. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | N/A |
| Function | Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone. |
| Protein Length | 1412 Amino acids |
| Molecular weight | 151292 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2508058 2 PubMed abstract 10731132 3 PubMed abstract 12537572 4 PubMed abstract 8223281 |
| Hormone | Detail in HMRbase |
| Gene ID | 39999 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |