A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21326 |
| Swiss-prot Accession number | P08235 (Sequence in FASTA format) |
| Description | RecName: Mineralocorticoid receptor;MR;Alternative Name: Nuclear receptor subfamily 3 group C member 2; |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. |
| Post translational modification | Phosphorylated. |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Protein Length | 984 Amino acids |
| Molecular weight | 107067 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 3037703 2 PubMed abstract 11518808 3 PubMed abstract 15815621 4 PubMed abstract 9662404 5 PubMed abstract 1655735 6 PubMed abstract 7495694 7 PubMed abstract 9141514 8 PubMed abstract 9392437 9 PubMed abstract 9724527 10 PubMed abstract 10760050 11 PubMed abstract 10935545 12 PubMed abstract 11350956 13 PubMed abstract 15967794 14 PubMed abstract 16061183 15 PubMed abstract 15908963 16 PubMed abstract 10391210 17 PubMed abstract 11134129 18 PubMed abstract 10884226 19 PubMed abstract 12483305 20 PubMed abstract 12788847 21 PubMed abstract 16954160 22 PubMed abstract 16959974 23 PubMed abstract 16972228 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 4306 |
| PDB ID | 1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX |
| Drugpedia | wiki |
| Comments |