A database of hormones and their receptors
Peptide Hormone

Search Result - 1

HMRbase accession number11380
Swiss-prot Accession numberP06883 (Sequence in FASTA format)
DescriptionGlucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the glucagon family.
Tissue SpecificityGlucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract
Post translational modification Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity
Protein Length180 Amino acids
Molecular weight20846
References1  PubMed abstract 6094539
2  PubMed abstract 6548696
3  PubMed abstract 3528148
4  PubMed abstract 7937770
5  PubMed abstract 11564680
6  PubMed abstract 8721980
7  PubMed abstract 1692320
8  PubMed abstract 14719035
9  PubMed abstract 12554744
10  PubMed abstract 12626323
11  PubMed abstract 10322410
12  PubMed abstract 10605628
Domain NameHormone_2  
Hormone NameGlicentin
Mature Hormone SequenceHAPQDTEENARSFPASQTEPLEDPDQINEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA
Position of mature hormone in Pre-Hormone protein69 Residues from position (21-89)
ReceptorP30082    Detail in HMRbase   
Gene ID24952      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 2

HMRbase accession number11381
Swiss-prot Accession numberP06883 (Sequence in FASTA format)
DescriptionGlucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the glucagon family.
Tissue SpecificityGlucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract
Post translational modification Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
FunctionOxyntomodulin significantly reduces food intake
Protein Length180 Amino acids
Molecular weight20846
References1  PubMed abstract 6094539
2  PubMed abstract 6548696
3  PubMed abstract 3528148
4  PubMed abstract 7937770
5  PubMed abstract 11564680
6  PubMed abstract 8721980
7  PubMed abstract 1692320
8  PubMed abstract 14719035
9  PubMed abstract 12554744
10  PubMed abstract 12626323
11  PubMed abstract 10322410
12  PubMed abstract 10605628
Domain NameHormone_2  
Hormone NameOxyntomodulin
Mature Hormone SequenceHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIA
Position of mature hormone in Pre-Hormone protein37 Residues from position (53-89)
ReceptorP30082    Detail in HMRbase   
Gene ID24952      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 3

HMRbase accession number11382
Swiss-prot Accession numberP06883 (Sequence in FASTA format)
DescriptionGlucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the glucagon family.
Tissue SpecificityGlucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract
Post translational modification Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes
Protein Length180 Amino acids
Molecular weight20846
References1  PubMed abstract 6094539
2  PubMed abstract 6548696
3  PubMed abstract 3528148
4  PubMed abstract 7937770
5  PubMed abstract 11564680
6  PubMed abstract 8721980
7  PubMed abstract 1692320
8  PubMed abstract 14719035
9  PubMed abstract 12554744
10  PubMed abstract 12626323
11  PubMed abstract 10322410
12  PubMed abstract 10605628
Domain NameHormone_2  
Hormone NameGlucagon
Mature Hormone SequenceHSQGTFTSDYSKYLDSRRAQDFVQWLMNT
Position of mature hormone in Pre-Hormone protein29 Residues from position (53-81)
ReceptorP30082    Detail in HMRbase   
Gene ID24952      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 4

HMRbase accession number11383
Swiss-prot Accession numberP06883 (Sequence in FASTA format)
DescriptionGlucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the glucagon family.
Tissue SpecificityGlucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract
Post translational modification Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferaton. Inhibits beta cell apoptosis
Protein Length180 Amino acids
Molecular weight20846
References1  PubMed abstract 6094539
2  PubMed abstract 6548696
3  PubMed abstract 3528148
4  PubMed abstract 7937770
5  PubMed abstract 11564680
6  PubMed abstract 8721980
7  PubMed abstract 1692320
8  PubMed abstract 14719035
9  PubMed abstract 12554744
10  PubMed abstract 12626323
11  PubMed abstract 10322410
12  PubMed abstract 10605628
Domain NameHormone_2  
Hormone NameGlucagon-like peptide 1
Mature Hormone SequenceHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG
Position of mature hormone in Pre-Hormone protein37 Residues from position (92-128)
ReceptorP30082    Detail in HMRbase   
Gene ID24952      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 5

HMRbase accession number11384
Swiss-prot Accession numberP06883 (Sequence in FASTA format)
DescriptionGlucagon precursor [Contains: Glicentin; Glicentin-related polypeptide(GRPP); Oxyntomodulin (OXY) (OXM); Glucagon; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-likepeptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2)].
Source organismRattus norvegicus (Rat)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the glucagon family.
Tissue SpecificityGlucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract
Post translational modification Proglucagon is posttranslationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by posttranslational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Function GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability
Protein Length180 Amino acids
Molecular weight20846
References1  PubMed abstract 6094539
2  PubMed abstract 6548696
3  PubMed abstract 3528148
4  PubMed abstract 7937770
5  PubMed abstract 11564680
6  PubMed abstract 8721980
7  PubMed abstract 1692320
8  PubMed abstract 14719035
9  PubMed abstract 12554744
10  PubMed abstract 12626323
11  PubMed abstract 10322410
12  PubMed abstract 10605628
Domain NameHormone_2  
Hormone NameGlucagon-like peptide 2
Mature Hormone SequenceHADGSFSDEMNTILDNLATRDFINWLIQTKITD
Position of mature hormone in Pre-Hormone protein33 Residues from position (146-178)
ReceptorP30082    Detail in HMRbase   
Gene ID24952      
PDB IDN/A
Drugpediawiki
Comments