A database of hormones and their receptors
Peptide Hormone

Search Result - 1

HMRbase accession number11344
Swiss-prot Accession numberP01350 (Sequence in FASTA format)
DescriptionGastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityN/A
Post translational modification Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length101 Amino acids
Molecular weight11394
References1  PubMed abstract 3034736
2  PubMed abstract 6087340
3  PubMed abstract 6324077
4  PubMed abstract 6574456
5  PubMed abstract 6322186
6  PubMed abstract 6689486
7  PubMed abstract 15489334
8  PubMed abstract 8055952
9  PubMed abstract 5921183
10  PubMed abstract 2730647
11  PubMed abstract 5822140
12  PubMed abstract 7530658
13  PubMed abstract 11052986
Domain NameGastrin  
Hormone NameGastrin-71
Mature Hormone SequenceSWKPRSQQPDAPLGTGANRDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein71 Residues from position (22-92)
ReceptorP32239    Detail in HMRbase   
Gene ID2520      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 2

HMRbase accession number11345
Swiss-prot Accession numberP01350 (Sequence in FASTA format)
DescriptionGastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityN/A
Post translational modification Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length101 Amino acids
Molecular weight11394
References1  PubMed abstract 3034736
2  PubMed abstract 6087340
3  PubMed abstract 6324077
4  PubMed abstract 6574456
5  PubMed abstract 6322186
6  PubMed abstract 6689486
7  PubMed abstract 15489334
8  PubMed abstract 8055952
9  PubMed abstract 5921183
10  PubMed abstract 2730647
11  PubMed abstract 5822140
12  PubMed abstract 7530658
13  PubMed abstract 11052986
Domain NameGastrin  
Hormone NameGastrin-52
Mature Hormone SequenceDLELPWLEQQGPASHHRRQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein52 Residues from position (41-92)
ReceptorP32239    Detail in HMRbase   
Gene ID2520      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 3

HMRbase accession number11346
Swiss-prot Accession numberP01350 (Sequence in FASTA format)
DescriptionGastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityN/A
Post translational modification Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length101 Amino acids
Molecular weight11394
References1  PubMed abstract 3034736
2  PubMed abstract 6087340
3  PubMed abstract 6324077
4  PubMed abstract 6574456
5  PubMed abstract 6322186
6  PubMed abstract 6689486
7  PubMed abstract 15489334
8  PubMed abstract 8055952
9  PubMed abstract 5921183
10  PubMed abstract 2730647
11  PubMed abstract 5822140
12  PubMed abstract 7530658
13  PubMed abstract 11052986
Domain NameGastrin  
Hormone NameBig gastrin
Mature Hormone SequenceQLGPQGPPHLVADPSKKQGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein34 Residues from position (59-92)
ReceptorP32239    Detail in HMRbase   
Gene ID2520      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 4

HMRbase accession number11347
Swiss-prot Accession numberP01350 (Sequence in FASTA format)
DescriptionGastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityN/A
Post translational modification Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length101 Amino acids
Molecular weight11394
References1  PubMed abstract 3034736
2  PubMed abstract 6087340
3  PubMed abstract 6324077
4  PubMed abstract 6574456
5  PubMed abstract 6322186
6  PubMed abstract 6689486
7  PubMed abstract 15489334
8  PubMed abstract 8055952
9  PubMed abstract 5921183
10  PubMed abstract 2730647
11  PubMed abstract 5822140
12  PubMed abstract 7530658
13  PubMed abstract 11052986
Domain NameGastrin  
Hormone NameGastrin
Mature Hormone SequenceQGPWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein17 Residues from position (76-92)
ReceptorP32239    Detail in HMRbase   
Gene ID2520      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 5

HMRbase accession number11348
Swiss-prot Accession numberP01350 (Sequence in FASTA format)
DescriptionGastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityN/A
Post translational modification Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length101 Amino acids
Molecular weight11394
References1  PubMed abstract 3034736
2  PubMed abstract 6087340
3  PubMed abstract 6324077
4  PubMed abstract 6574456
5  PubMed abstract 6322186
6  PubMed abstract 6689486
7  PubMed abstract 15489334
8  PubMed abstract 8055952
9  PubMed abstract 5921183
10  PubMed abstract 2730647
11  PubMed abstract 5822140
12  PubMed abstract 7530658
13  PubMed abstract 11052986
Domain NameGastrin  
Hormone NameGastrin-14
Mature Hormone SequenceWLEEEEEAYGWMDF
Position of mature hormone in Pre-Hormone protein14 Residues from position (79-92)
ReceptorP32239    Detail in HMRbase   
Gene ID2520      
PDB IDN/A
Drugpediawiki
Comments


Search Result - 6

HMRbase accession number11349
Swiss-prot Accession numberP01350 (Sequence in FASTA format)
DescriptionGastrin precursor [Contains: Gastrin-71 (Component I); Gastrin-52(G52); Big gastrin (Gastrin-34) (G34) (Component II); Gastrin(Gastrin-17) (G17) (Component III); Gastrin-14 (G14); Gastrin-6 (G6)].
Source organismHomo sapiens (Human)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo.
Subcellular locationSecreted
Developmental StageN/A
Similarity Belongs to the gastrin/cholecystokinin family.
Tissue SpecificityN/A
Post translational modification Two different processing pathways probably exist in antral G- cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation of Tyr-87 blocks peptide degradation and enhances activity.
FunctionGastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Protein Length101 Amino acids
Molecular weight11394
References1  PubMed abstract 3034736
2  PubMed abstract 6087340
3  PubMed abstract 6324077
4  PubMed abstract 6574456
5  PubMed abstract 6322186
6  PubMed abstract 6689486
7  PubMed abstract 15489334
8  PubMed abstract 8055952
9  PubMed abstract 5921183
10  PubMed abstract 2730647
11  PubMed abstract 5822140
12  PubMed abstract 7530658
13  PubMed abstract 11052986
Domain NameGastrin  
Hormone NameGastrin-6
Mature Hormone SequenceYGWMDF
Position of mature hormone in Pre-Hormone protein6 Residues from position (87-92)
ReceptorP32239    Detail in HMRbase   
Gene ID2520      
PDB IDN/A
Drugpediawiki
Comments