A database of hormones and their receptors
Receptor

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HMRbase accession number21215
Swiss-prot Accession numberO97960 (Sequence in FASTA format)
DescriptionRecName: Androgen receptor;Alternative Name: Dihydrotestosterone receptor;Alternative Name: Nuclear receptor subfamily 3 group C member 4;
Source organismPapio hamadryas (Hamadryas baboon)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
Subcellular locationNucleus (By similarity)
Developmental StageN/A
Similarity Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue SpecificityN/A
Post translational modification Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-510 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression (By similarity).
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 (By similarity).
Protein Length895 Amino acids
Molecular weight96479
Domain NameAndrogen_recep  Hormone_recep  zf-C4  
References1  PubMed abstract 9732460
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Gene IDN/A
PDB IDN/A
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