A database of hormones and their receptors
Receptor

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HMRbase accession number21368
Swiss-prot Accession numberO54915 (Sequence in FASTA format)
DescriptionRecName: Nuclear receptor subfamily 1 group I member 2;Alternative Name: Pregnane X receptor;Alternative Name: Orphan nuclear receptor PXR
Source organismMus musculus (Mouse)
Taxonomical ClassificationEukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus.
Subcellular locationNucleus (By similarity)
Developmental StageN/A
Similarity Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.
Tissue SpecificityN/A
Post translational modification N/A
Function Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics (By similarity).
Protein Length431 Amino acids
Molecular weight49567
Domain NameHormone_recep  zf-C4  
References1  PubMed abstract 9489701
2  PubMed abstract 16141072
HormoneDetail in HMRbase   
Detail in HMRbase   
Detail in HMRbase   
Detail in HMRbase   
Gene ID18171      
PDB IDN/A
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