A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21511 |
| Swiss-prot Accession number | O13124 (Sequence in FASTA format) |
| Description | Vitamin D3 receptor;VDR;Alternative Name: 1,25-dihydroxyvitamin D3 receptor;Alternative Name: Nuclear receptor subfamily 1 group I member 1 |
| Source organism | Xenopus laevis (African clawed frog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | First detected at stage 13. Increases gradually and peaks at stage 57-61 then decreases to the level seen in adult. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Detected in all tissues examined. Highest level in small intestine and skin. |
| Post translational modification | N/A |
| Function | Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Plays a central role in calcium homeostasis (By similarity). |
| Protein Length | 422 Amino acids |
| Molecular weight | 48188 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9165021 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 378575 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |