A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21285 |
| Swiss-prot Accession number | O08537 (Sequence in FASTA format) |
| Description | RecName: Estrogen receptor beta;ER-beta;Alternative Name: Nuclear receptor subfamily 3 group A member 2; |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in prostate, ovary, Leydig cells and in epithelium of the efferent ductules and of the initial segment of the epididymis. |
| Post translational modification | N/A |
| Function | Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation. |
| Protein Length | 530 Amino acids |
| Molecular weight | 59012 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9058381 2 PubMed abstract 9280064 3 PubMed abstract 9192892 4 PubMed abstract 9607809 5 PubMed abstract 9685228 6 PubMed abstract 10995228 7 PubMed abstract 10788465 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |