| HMRbase accession number | 21645 |
| Swiss-prot Accession number | P35408 (Sequence in FASTA format) |
| Description | Prostaglandin E2 receptor EP4 subtype;PGE receptor, EP4 subtype;Alternative Name: Prostanoid EP4 receptor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. |
| Post translational modification | N/A |
| Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| Protein Length | 488 Amino acids |
| Molecular weight | 53119 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8163486
2 PubMed abstract 8250933
3 PubMed abstract 8661119
4 PubMed abstract 8862514
5 PubMed abstract 15489334
6 PubMed abstract 16424369
|
| Hormone | Detail in HMRbase
Detail in HMRbase
|
| Gene ID | 5734 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | |
A database of hormones and their receptors