A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21644 |
| Swiss-prot Accession number | P43115 (Sequence in FASTA format) |
| Description | Prostaglandin E2 receptor EP3 subtype;PGE receptor, EP3 subtype;PGE2-R;Alternative Name: Prostanoid EP3 receptor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. |
| Post translational modification | N/A |
| Function | Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity). |
| Protein Length | 390 Amino acids |
| Molecular weight | 43310 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 8307176 2 PubMed abstract 7883006 3 PubMed abstract 8117308 4 PubMed abstract 8135729 5 PubMed abstract 7981210 6 PubMed abstract 7476918 7 PubMed abstract 8075855 8 PubMed abstract 9073510 9 PubMed abstract 16710414 10 PubMed abstract 15489334 11 PubMed abstract 18023986 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 5733 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |