A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21640 |
| Swiss-prot Accession number | P43119 (Sequence in FASTA format) |
| Description | Prostacyclin receptor;Alternative Name: Prostanoid IP receptor;Alternative Name: PGI receptor;Alternative Name: Prostaglandin I2 receptor |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | N/A |
| Post translational modification | Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling. Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C. |
| Function | Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
| Protein Length | 386 Amino acids |
| Molecular weight | 40956 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 7512962 2 PubMed abstract 7514139 3 PubMed abstract 7923647 4 PubMed abstract 7665161 5 PubMed abstract 15489334 6 PubMed abstract 11895442 7 PubMed abstract 12488443 8 PubMed abstract 15194446 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 5739 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |