A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21638 |
| Swiss-prot Accession number | Q9NS75 (Sequence in FASTA format) |
| Description | Cysteinyl leukotriene receptor 2;CysLTR2;Alternative Name: HG57;Alternative Name: HPN321;Alternative Name: hGPCR21 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Cell membrane; Multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells. |
| Post translational modification | N/A |
| Function | Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4. |
| Protein Length | 346 Amino acids |
| Molecular weight | 39635 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 10913337 2 PubMed abstract 10851239 3 PubMed abstract 11093801 4 PubMed abstract 12044878 5 PubMed abstract 15057823 6 PubMed abstract 15489334 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | 57105 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |