| HMRbase accession number | 21496 |
| Swiss-prot Accession number | P18102 (Sequence in FASTA format) |
| Description | Protein tailless;Alternative Name: Nuclear receptor subfamily 2 group E member 2 |
| Source organism | Drosophila melanogaster (Fruit fly) |
| Taxonomical Classification | Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha;Ephydroidea; Drosophilidae; Drosophila; Sophophora. |
| Subcellular location | Nucleus (Potential) |
| Developmental Stage | During stage 10 found in the anterior part of the visual system that later gives rise to the anterior lip of the optic lobe. At stage 12 also found in the posterior lip of the optic lobe. In third larval instar expressed in the optic lobe of the larval brain and in the eye antennal disk, both in antennal and eye portion. |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Brain and peripheral nervous system. |
| Post translational modification | N/A |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate. |
| Protein Length | 452 Amino acids |
| Molecular weight | 50549 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2364433
2 PubMed abstract 8430097
3 PubMed abstract 10731132
4 PubMed abstract 12537572
5 PubMed abstract 10357938
|
| Hormone | N/A |
| Gene ID | 43656 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
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