A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21494 |
| Swiss-prot Accession number | Q9GKL2 (Sequence in FASTA format) |
| Description | Steroidogenic factor 1;STF-1;SF-1;Alternative Name: Nuclear receptor subfamily 5 group A member 1 |
| Source organism | Equus caballus (Horse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Acetylation stimulates the transcriptional activity (By similarity). |
| Function | Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO-NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3 (By similarity). |
| Protein Length | 461 Amino acids |
| Molecular weight | 51644 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 11108279 |
| Hormone | N/A |
| Gene ID | 100033902 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |