A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21477 |
| Swiss-prot Accession number | P51128 (Sequence in FASTA format) |
| Description | Retinoic acid receptor RXR-alpha;Alternative Name: Retinoid X receptor alpha;Alternative Name: Nuclear receptor subfamily 2 group B member 1 |
| Source organism | Xenopus laevis (African clawed frog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus. |
| Subcellular location | Nucleus |
| Developmental Stage | It is synthesized during oogenesis and persists during early cleavage, levels drop before gastrulation and remain low until the tailbud stage, and then increase in the later stages. |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Sumoylated on Lys-134; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6 (By similarity). |
| Function | Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA) (By similarity). |
| Protein Length | 488 Amino acids |
| Molecular weight | 53469 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 1312717 2 PubMed abstract 9658407 3 PubMed abstract 16912044 |
| Hormone | N/A |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |