A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21475 |
| Swiss-prot Accession number | P28700 (Sequence in FASTA format) |
| Description | Retinoic acid receptor RXR-alpha;Alternative Name: Retinoid X receptor alpha;Alternative Name: Nuclear receptor subfamily 2 group B member 1 |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Sumoylated on Lys-113; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6 (By similarity). |
| Function | Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. |
| Protein Length | 467 Amino acids |
| Molecular weight | 51217 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 1310259 2 PubMed abstract 1312497 3 PubMed abstract 7838715 4 PubMed abstract 10788465 5 PubMed abstract 17595322 |
| Hormone | N/A |
| Gene ID | 20181 |
| PDB ID | 1DKF 1XDK |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |