A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21474 |
| Swiss-prot Accession number | P19793 (Sequence in FASTA format) |
| Description | Retinoic acid receptor RXR-alpha;Alternative Name: Retinoid X receptor alpha;Alternative Name: Nuclear receptor subfamily 2 group B member 1 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Highly expressed in liver, also found in lung, kidney and heart. |
| Post translational modification | Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6. |
| Function | Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer (By similarity). |
| Protein Length | 462 Amino acids |
| Molecular weight | 50811 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2159111 2 PubMed abstract 1310260 3 PubMed abstract 9267036 4 PubMed abstract 10567404 5 PubMed abstract 11259580 6 PubMed abstract 15047147 7 PubMed abstract 14981089 8 PubMed abstract 16574651 9 PubMed abstract 16912044 10 PubMed abstract 7925381 11 PubMed abstract 7746322 12 PubMed abstract 7760929 13 PubMed abstract 9698548 |
| Hormone | N/A |
| Gene ID | 6256 |
| PDB ID | 1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |