A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21450 |
| Swiss-prot Accession number | P11416 (Sequence in FASTA format) |
| Description | Retinoic acid receptor alpha;RAR-alpha;Alternative Name: Nuclear receptor subfamily 1 group B member 1 |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity. |
| Function | This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression. |
| Protein Length | 462 Amino acids |
| Molecular weight | 50735 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2544807 2 PubMed abstract 8383767 3 PubMed abstract 1846598 4 PubMed abstract 1320576 5 PubMed abstract 2174108 6 PubMed abstract 15489334 7 PubMed abstract 17205979 8 PubMed abstract 9230306 9 PubMed abstract 9192892 10 PubMed abstract 10788465 |
| Hormone | N/A |
| Gene ID | 19401 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |