| HMRbase accession number | 21445 |
| Swiss-prot Accession number | Q7ZTI3 (Sequence in FASTA format) |
| Description | Retinoic acid receptor alpha-B;RAR-alpha-B;Alternative Name: Retinoic acid receptor alpha-2.B;RAR-alpha-2.B;Alternative Name: Nuclear receptor subfamily 1 group B member 1-B |
| Source organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;Cyprinidae; Danio. |
| Subcellular location | Nucleus |
| Developmental Stage | Expressed both maternally and zygotically. At 9 hours post-fertilization (hpf), expressed in the dorsal epiblast and prospective tail regions, but absent from the ventral epiblast. At 10 hpf, expressed in presumptive diencephalon and hindbrain, in tissue lateral to the head, the posterior neural plate, tail bud and adjacent mesoderm. During somitogenesis, head and tail expression remains. At 24 hpf, low levels of ubiquitous expression with stronger expression in eyes, hindbrain and spinal cord; in hindbrain the anterior border is at rhombomeres 3-4. Also expressed in non-neural tissues including pharyngeal endoderm, mesenchyme and tail bud. At 48 hpf, expression is maintained in hindbrain, eyes, diencephalon and the pharyngeal region, and is also observed in forebrain, midbrain and pectoral fin bud. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | In the embryo, zygotic expression largely overlaps that of raraa, with high levels in hindbrain, lateral mesoderm and tail bud, but in later stages rarab is expressed more broadly in the brain, pectoral fin bud and pharyngeal arches. |
| Post translational modification | N/A |
| Function | This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression. |
| Protein Length | 458 Amino acids |
| Molecular weight | 50525 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 16455309
|
| Hormone | N/A |
| Gene ID | 555364 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
A database of hormones and their receptors