| HMRbase accession number | 21444 |
| Swiss-prot Accession number | Q90271 (Sequence in FASTA format) |
| Description | Retinoic acid receptor alpha-A;RAR-alpha-A;Alternative Name: Retinoic acid receptor alpha;zRAR alpha;Alternative Name: Retinoic acid receptor alpha-2.A;RAR-alpha-2.A;Alternative Name: Nuclear receptor subfamily 1 group B member 1-A |
| Source organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;Cyprinidae; Danio. |
| Subcellular location | Nucleus |
| Developmental Stage | Not expressed maternally. First detected at 8 hours post-fertilization (hpf) during gastrulation. Expression then increases, reaching a peak at 24 hpf and decreasing from 30- 48 hpf. At 9 hpf, expressed throughout the dorsal epiblast except at the dorsal midline, and ventrally in prospective tail and head regions. At 10-11 hpf, expressed in presumptive hindbrain, posterior neural plate, lateral mesoderm and tail bud. At 12 hpf, strongly expressed in the neural epithelium and tail bud and expressed at low levels elsewhere including the eye. At 24 hpf, restricted to the hindbrain with an anterior border at rhombomere 6-7, to anterior spinal cord and to head mesenchyme just posterior to the otic vesicle. At 48 hpf, hindbrain expression remains and there is diffuse expression in non-neural tissue in the pharyngeal region. |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | In the embryo, zygotic expression largely overlaps that of rarab, with high levels in hindbrain, lateral mesoderm and tail bud. In the adult, strong expression in brain and muscle, weaker expression in ovary, liver and digestive tract. |
| Post translational modification | N/A |
| Function | This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression. |
| Protein Length | 444 Amino acids |
| Molecular weight | 49924 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7918098
2 PubMed abstract 16455309
|
| Hormone | N/A |
| Gene ID | 30680 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
A database of hormones and their receptors