A database of hormones and their receptors| A database of hormones and their receptors |
|
|
|
|
|
|
|
| HMRbase accession number | 21428 |
| Swiss-prot Accession number | P37231 (Sequence in FASTA format) |
| Description | Peroxisome proliferator-activated receptor gamma;PPAR-gamma;Alternative Name: Nuclear receptor subfamily 1 group C member 3 |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also are detectable in placenta, lung and ovary. |
| Post translational modification | N/A |
| Function | Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. |
| Protein Length | 505 Amino acids |
| Molecular weight | 57620 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9065481 2 PubMed abstract 8702406 3 PubMed abstract 9144532 4 PubMed abstract 7787419 5 PubMed abstract 9356045 6 PubMed abstract 8706692 7 PubMed abstract 15489334 8 PubMed abstract 10681503 9 PubMed abstract 11971969 10 PubMed abstract 15047147 11 PubMed abstract 15687259 12 PubMed abstract 9813012 13 PubMed abstract 9744270 14 PubMed abstract 10882139 15 PubMed abstract 11698662 16 PubMed abstract 11587644 17 PubMed abstract 12672231 18 PubMed abstract 15258145 19 PubMed abstract 15056000 20 PubMed abstract 15974597 21 PubMed abstract 15976031 22 PubMed abstract 16919947 23 PubMed abstract 16451087 24 PubMed abstract 16640330 25 PubMed abstract 9425261 26 PubMed abstract 9753710 27 PubMed abstract 9806549 28 PubMed abstract 10407229 29 PubMed abstract 10523018 30 PubMed abstract 10394368 31 PubMed abstract 10622252 32 PubMed abstract 12453919 33 PubMed abstract 11788685 34 PubMed abstract 14569127 35 PubMed abstract 15356014 36 PubMed abstract 15562396 |
| Hormone | Detail in HMRbase Detail in HMRbase |
| Gene ID | 5468 |
| PDB ID | 1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZEO 1ZGY 2ATH 2F4B 2FVJ 2G0G 2G0H 2GTK 2HFP 2HWQ 2HWR 2I4J 2I4P 2I4Z 2OM9 2P4Y 2POB 2PRG 2Q59 2Q5P 2Q5S 2Q61 2Q6R 2Q6S 2QMV 3CS8 3CWD 3PRG 4PRG |
| Drugpedia | wiki |
| Comments |