A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21387 |
| Swiss-prot Accession number | P70052 (Sequence in FASTA format) |
| Description | Nuclear receptor subfamily 2 group E member 1;Alternative Name: Nuclear receptor TLX;Alternative Name: Protein tailless homolog;Tll;xTLL |
| Source organism | Xenopus laevis (African clawed frog) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae;Xenopodinae; Xenopus; Xenopus. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Prominent expression in the embryonal optic stalk and the distal tip of the forming vesicle. In tadpole-stage embryos predominantly found in the ciliary margin of the optic cup. |
| Post translational modification | N/A |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Involved in the regulation of early eye development. |
| Protein Length | 386 Amino acids |
| Molecular weight | 42974 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9609825 |
| Hormone | N/A |
| Gene ID | 378567 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |