| HMRbase accession number | 21385 |
| Swiss-prot Accession number | Q64104 (Sequence in FASTA format) |
| Description | Nuclear receptor subfamily 2 group E member 1;Alternative Name: Nuclear receptor TLX;Alternative Name: Protein tailless homolog;Tll;mTll |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | Expression is first detected on 8 dpc and increases until 13.5 dpc, then sharply decreases from day 13 dpc until 18 dpc. Expression is barely detected in newborn brains but increases again after birth. |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Expressed in embryonic developing forebrain and in dorsal midbrain. Outside the neural epithelium only found in the surface ectoderm at the site of nasal placode formation, where subsequently the nasal and olfactory epithelium is formed. Also expressed in adult brain. |
| Post translational modification | N/A |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. Tlx-/-mice show central nervous system cortical defects (reduction in the size of rhinencephalic and limbic structures of the brain, including the olfactory, infrarhinal and entorhinal cortex, amygdala, and dentate gyrus) and progressive retinal and optic nerve degradation with associated blindness. |
| Protein Length | 385 Amino acids |
| Molecular weight | 42619 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 7720587
2 PubMed abstract 15489334
3 PubMed abstract 10706625
|
| Hormone | N/A |
| Gene ID | 21907 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |
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