A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21384 |
| Swiss-prot Accession number | Q9Y466 (Sequence in FASTA format) |
| Description | Nuclear receptor subfamily 2 group E member 1;Alternative Name: Nuclear receptor TLX;Alternative Name: Protein tailless homolog;Tll;hTll |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Nucleus (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. |
| Post translational modification | N/A |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development (By similarity). |
| Protein Length | 385 Amino acids |
| Molecular weight | 42589 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 9628820 2 PubMed abstract 11073974 3 PubMed abstract 14574404 4 PubMed abstract 15489334 5 PubMed abstract 18187866 |
| Hormone | N/A |
| Gene ID | 7101 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |