A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21330 |
| Swiss-prot Accession number | P22199 (Sequence in FASTA format) |
| Description | RecName: Mineralocorticoid receptor;MR;Alternative Name: Nuclear receptor subfamily 3 group C member 2; |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Cytoplasm (By similarity). Nucleus (By similarity). Endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane (By similarity) |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Detected in liver, brain, heart, kidney, colon, aorta, hippocampus, hypothalamus and adrenal fasciculata. |
| Post translational modification | Phosphorylated. |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Protein Length | 981 Amino acids |
| Molecular weight | 106737 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2558305 2 PubMed abstract 7495694 3 PubMed abstract 7982810 4 PubMed abstract 8618925 5 PubMed abstract 9111344 6 PubMed abstract 9677313 7 PubMed abstract 10687858 |
| Hormone | Detail in HMRbase |
| Gene ID | 25672 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |