A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21315 |
| Swiss-prot Accession number | P22449 (Sequence in FASTA format) |
| Description | RecName: Hepatocyte nuclear factor 4-alpha;HNF-4-alpha;Alternative Name: Transcription factor HNF-4;Alternative Name: Nuclear receptor subfamily 2 group A member 1;Alternative Name: Transcription factor 14; |
| Source organism | Rattus norvegicus (Rat) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Rattus. |
| Subcellular location | Nucleus |
| Developmental Stage | N/A |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | Liver, kidney and intestine. |
| Post translational modification | Phosphorylated in the recognition sequence R-R-S-S near the DNA-binding domain; phosphorylation results in decrease in DNA- binding activity. Phosphorylation of HNF4 depends on the diet and is decreased by a carbohydrate-rich diet and is increased by fasting. The N-terminus is blocked. |
| Function | Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1- alpha. May be essential for development of the liver, kidney and intestine. |
| Protein Length | 474 Amino acids |
| Molecular weight | 52712 |
| Domain Name | Hormone_recep zf-C4 |
| References | 1 PubMed abstract 2279702 2 PubMed abstract 1610903 3 PubMed abstract 9234678 4 PubMed abstract 12193589 |
| Hormone | N/A |
| Gene ID | 25735 |
| PDB ID | 1M7W |
| Drugpedia | wiki |
| Comments | !Hormone for this Receptor are either unknown or have not yet been curated |