A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21310 |
| Swiss-prot Accession number | P35547 (Sequence in FASTA format) |
| Description | RecName: Glucocorticoid receptor;GR;Alternative Name: Nuclear receptor subfamily 3 group C member 1; Fragment; |
| Source organism | Ovis aries (Sheep) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;Pecora; Bovidae; Caprinae; Ovis. |
| Subcellular location | Cytoplasm (By similarity). Nucleus (By similarity). Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding (By similarity) |
| Developmental Stage | Detected in hypothalamus, anterior pituitary gland and adrenals in fetuses at days 60-70, 100-110, 125-130. In newborn, levels increased significantly in the hypothalamus and pituitary gland but decreased to undetectable levels in the adrenal. |
| Similarity | Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain. |
| Tissue Specificity | N/A |
| Post translational modification | Increased proteasome-mediated degradation in response to glucocorticoids (By similarity). Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids (By similarity). Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity). Sumoylated; this reduces transcription transactivation (By similarity). |
| Function | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity). |
| Protein Length | 314 Amino acids |
| Molecular weight | 33562 |
| Domain Name | GCR zf-C4 |
| References | 1 PubMed abstract 1515021 |
| Hormone | Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |