A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21174 |
| Swiss-prot Accession number | Q99705 (Sequence in FASTA format) |
| Description | Melanin-concentrating hormone receptor 1 (MCH receptor 1) (MCHR-1)(MCH-R1) (MCH1R) (MCH-1R) (MCHR) (G-protein coupled receptor 24)(Somatostatin receptor-like protein) (SLC-1). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. |
| Post translational modification | N/A |
| Function | Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. |
| Protein Length | 422 Amino acids |
| Molecular weight | 45963 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 10441476 2 PubMed abstract 15941924 3 Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,Phelan M., Farmer A.; "Cloning of human full-length CDSs in BD Creator(TM) system donorvector."; Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. 4 PubMed abstract 15461802 5 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. 6 PubMed abstract 10591208 7 PubMed abstract 15489334 8 PubMed abstract 8977118 9 PubMed abstract 10421367 10 PubMed abstract 15166293 11 PubMed abstract 15340116 |
| Hormone | P20382 Detail in HMRbase Q16048 Detail in HMRbase Q9BQD1 Detail in HMRbase |
| Gene ID | 2847 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |