A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21170 |
| Swiss-prot Accession number | Q969V1 (Sequence in FASTA format) |
| Description | Melanin-concentrating hormone receptor 2 (MCH receptor 2) (MCHR-2)(MCH-R2) (MCH2R) (MCH-2R) (MCH2) (G-protein coupled receptor 145)(GPRv17). |
| Source organism | Homo sapiens (Human) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;Catarrhini; Hominidae; Homo. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Tissue Specificity | Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus. |
| Post translational modification | N/A |
| Function | Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis. |
| Protein Length | 340 Amino acids |
| Molecular weight | 38849 |
| Domain Name | 7tm_1 |
| References | 1 PubMed abstract 11355873 2 PubMed abstract 11404457 3 PubMed abstract 11459838 4 PubMed abstract 11274220 5 Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M.,Kamohara M., Saito T., Soga T., Saito Y., Oda T., Masuho Y.,Furuichi K.; "Molecular characterization of a novel melanin-concentrating hormonereceptor: evidence of its expression in lateral hypothalamus."; Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. 6 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. 7 PubMed abstract 14574404 8 PubMed abstract 15489334 9 PubMed abstract 15340116 10 PubMed abstract 11355873 11 PubMed abstract 11404457 12 PubMed abstract 11459838 13 PubMed abstract 11274220 14 Kurama T., Matsumoto S., Takasaki J., Terai K., Matsumoto M.,Kamohara M., Saito T., Soga T., Saito Y., Oda T., Masuho Y.,Furuichi K.; "Molecular characterization of a novel melanin-concentrating hormonereceptor: evidence of its expression in lateral hypothalamus."; Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. 15 King M.M., Aronstam R.S., Sharma S.V.; "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org)."; Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. 16 PubMed abstract 14574404 17 PubMed abstract 15489334 18 PubMed abstract 15340116 |
| Hormone | P20382 Detail in HMRbase Q16048 Detail in HMRbase Q9BQD1 Detail in HMRbase |
| Gene ID | 84539 |
| PDB ID | N/A |
| Drugpedia | wiki |
| Comments |