A database of hormones and their receptors| A database of hormones and their receptors |
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| HMRbase accession number | 21107 |
| Swiss-prot Accession number | Q60748 (Sequence in FASTA format) |
| Description | Corticotropin-releasing factor receptor 2 precursor (CRF-R 2) (CRF2)(Corticotropin-releasing hormone receptor 2) (CRH-R 2) (CRF-RB) (CRH-R2). |
| Source organism | Mus musculus (Mouse) |
| Taxonomical Classification | Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;Muroidea; Muridae; Murinae; Mus. |
| Subcellular location | Membrane; multi-pass membrane protein |
| Developmental Stage | N/A |
| Similarity | Belongs to the G-protein coupled receptor 2 family. |
| Tissue Specificity | Highly expressed in the heart. Also expressed in lungs, skeletal muscle, gastrointestinal tract, epididymis, and brain. |
| Post translational modification | N/A |
| Function | This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
| Protein Length | 431 Amino acids |
| Molecular weight | 49923 |
| Domain Name | 7tm_2 HRM |
| References | 1 PubMed abstract 7708757 2 PubMed abstract 7755719 3 PubMed abstract 7565810 |
| Hormone | Q8CIT0 Detail in HMRbase |
| Gene ID | N/A |
| PDB ID | 1U34 2JNC 2JND |
| Drugpedia | wiki |
| Comments |